原著論文

Sakamachi Y, Morioka S, Mihaly SR, Takaesu G, Foley JF, Fessler MB, Ninomiya-Tsuji J. TAK1 regulates resident macrophages by protecting lysosomal integrity. Cell Death Dis. 2017 Feb 9;8(2):e2598. doi: 10.1038/cddis.2017.23.
http://www.nature.com/cddis/journal/v8/n2/full/cddis201723a.html
Toyonaga K, Torigoe S, Motomura Y, Kamichi T, Hayashi JM, Morita YS, Noguchi N, Chuma Y, Kiyohara H, Matsuo K, Tanaka H, Nakagawa Y, Sakuta T, Ohmura M, Yamamoto T, Umemura M, Matsuzaki G, Yoshikai Y, Yano I, Miyamoto T, Yamasaki S. C-Type lectin receptor DCAR recognizes mycobacterial phosphatidyl-inositol mannosides to promote a Th1 response during infection. 2016 Immunity 45 (6) 1245-1257. DOI: http://dx.doi.org/10.1016/j.immuni.2016.10.012
http://www.sciencedirect.com/science/article/pii/S1074761316304034
Umemura M, Okamoto-Yoshida Y, Yahagi A, Touyama S, Nakae S, Iwakura Y, Matsuzaki G. Involvement of IL-17A-producing TCR  T cells in late protective immunity against pulmonary Mycobacterium tuberculosis infection. 2016. Immun Inflamm Dis 4(4): 401-412. DOI:10.1002/iid3.121
http://onlinelibrary.wiley.com/doi/10.1002/iid3.121/abstract
Hatano S, Tamura T, Umemura M, Matsuzaki G, Ohara N, Yoshikai Y. Recombinant Mycobacterium bovis bacillus Calmette–Guérin expressing Ag85B-IL-7 fusion protein enhances IL-17A-producing innate γδ T cells. 2016 May 11, Vaccine 34 (22): 2490-2495. doi: 10.1016/j.vaccine.2016.03.096.
http://www.sciencedirect.com/science/article/pii/S0264410X16300937
Sai K, Morioka S, Takaesu G, Muthusamy N, Ghashghaei HT, Hanafusa H, Matsumoto K, Ninomiya-Tsuji J. TAK1 determines susceptibility to endoplasmic reticulum stress and leptin resistance in the hypothalamus. J Cell Sci. 2016 May 1;129(9):1855-65. doi: 10.1242/jcs.180505.
http://jcs.biologists.org/content/129/9/1855.long
Okita Y, Shiono T, Yahagi A, Hamada S, Umemura M, Matsuzaki G. Interleukin-22-Induced Antimicrobial Phospholipase PLA2G2A Mediates Protective Innate Immunity of Non-hematopoietic cells against Listeria monocytogenes. Infect. Immun. 2016 Feb 84(2):573-579. doi:10.1128/IAI.01000-15.
Fukui, M, Shinjo K, Umemura M, Harakuni T, Arakawa T, Matsuzaki G. Enhanced effect of BCG vaccination against pulmonary Mycobacterium tuberculosis infection in mice with lung Th17 response to mycobacterial HBHA antigen. Microbiol. Immunol. 2015 Dec;59(12):735-743. doi: 10.1111/1348-0421.12340.
Umikawa M, Umikawa A, Asato T, Takei K, Matsuzaki G, Kariya K. Angiopoietin-like protein 2 induces drastic proinflammatory responses in peritoneal cells. Biochem Biophys Res Commun. 2015 Nov 13;467(2):235-41. doi: 10.1016/j.bbrc.2015.09.183.
Akitsu A, Ishigame H, Kakuta S, Chung S-Y, Ikeda S, Shimizu K, Kubo S, Liu Y, Umemura M, Matsuzaki G, Yoshikai Y, Saijo S, Iwakura Y. IL-1 receptor antagonist-deficient mice develop autoimmune arthritis due to intrinsic activation of IL-17-producing CCR2+ V6+  T cells. 2015 Jun 25 Nat Commun.;6:7464. doi: 10.1038/ncomms8464.
Inafuku M, Matsuzaki G, Oku H. 2015. Intravenous Mycobacterium bovis Bacillus Calmette-Guerin Ameliorates Nonalcholic Fatty Liver Disease in Obese, Diabetic ob/ob Mice. PLoS One 10.1371/journal.pone.0128676.
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0128676
Masayuki Fukui, Noriko Yamabe, Hye-Joung Choi, KishorePolireddy, Qi Chen, Bao Ting Zhu. 2015. Role of Bcl-2 and Berlin-1 in Ascorbate-induced Autophagy in Human Pancreatic Cancer. Planta Medica 81:1-9.
http://dx.doi.org/10.1055/s-0035-1546132
Miyata T., Oshiro, S., Harakuni, T., Taira, T., Matsuzaki, G., Arakawa, T Physicochemically stable cholera toxin B subunit pentamer created by peripheral molecular constrains imposed by de novo-introduced intersubunit disulfide crosslink.. Vaccine 30: 4225-4232, 2012.
http://dx.doi.org/10.1016/j.vaccine.2012.04.047
Oshiro, K., Kohama, K., Umemura, M,, Uyttenhove, C., Inagaki-Ohara, K., Arakawa, T, Harada, H., Nakae, S., Iwakura, Y., Nishimaki, T., Matsuzaki, G. Interleukin-17A is involved in enhancement of tumor progression in murine intestine. Immunobiology 217: 54-60, 2012.
http://dx.doi.org/10.1016/j.imbio.2011.08.002
Miyata T., Harakuni, T., Taira, T., Matsuzaki, G., Arakawa, T. Merozoite surface protein-1 of Plasmodium yoelii fused via an oligosaccharide moiety of cholera toxin B subunit glycoprotein expressed in yeast induced protective immunity against lethal malaria infection in mice. Vaccine 30:948-958, 2012.
http://dx.doi.org/10.1016/j.vaccine.2011.11.059
Tafuku S, Miyata T, Tadano M, Mitsumata R, Kawakami H, Harakuni T, Sewaki T, Arakawa T. Japanese encephalitis virus structural and nonstructural proteins expressed in Escherichia coli induce protective immunity in mice. Microbes Infect. 14:169-176, 2012.
http://dx.doi.org/10.1016/j.micinf.2011.09.004
Miyata, T., Harakuni, T., Tsuboi, T., Aattabongkot, J., Ikehara, A., Tacibana, M., Torii, M., Matsuzaki, G., Arakawa, T. Tricomponent immunopotentiating system as a novel molecular design strategy for malaria vaccine development. Infect. Immune. 79: 4260-4275, 2011.
http://dx.doi.org/10.1128/IAI.05214-11
Ma, Y., Aymeric L., Locher, C., Mattarollo, S. R, Delahaye, N., F., Pereira, P., Boucontet, L., Apetoh, L., Ghironghelli, F., Casares, N., Lasarte, J. J., Matsuzaki, G., Ikuta, K., Ryffel, B., Benlagha, K., Tensiere, A., Ibrahim, N., Déchanet-Merville, J., Chaput, N., Smyth, M. J., Kroemer, G., Zitvoge, L. Contribution of IL-17-producing gamma delta T cells to the efficacy of anticancer chemotherapy. J. Exp. Med. 208: 491-503, 2011.
http://dx.doi.org/10.1084/jem.20100269
Miyata T, Harakuni T, Sugawa H, Sattabongkot, J, Kato A, Tachibana M, Torii M, Tsuboi T and Arakawa T. Adenovirus-vectored Plasmodium vivax ookinete surface protein, Pvs25, as a potential transmission-blocking vaccine. Vaccine 29: 2720-2726, 2011.
http://dx.doi.org/10.1016/j.vaccine.2011.01.083
Iijima M, Kadoya H, Hatahira S, Hiramatsu S, Jung G, Martin A, Quinn J, Jung J, Jeong SY, Choi EK, Arakawa T, Hinako F, Kusunoki M, Yoshimoto N, Niimi T, Tanizawa K and Kuroda S. Nanocapsules incorporating IgG Fc-binding domain derived from Staphylococcus aureus protein A for displaying IgGs on immunosensor chips. Biomaterials 32:1455-64. 2011
http://dx.doi.org/10.1016/j.biomaterials.2010.10.057
Kohama H, Harakuni T, Kikuchi M, Nara T, Takemura Y, Miyata T, Sato Y, Hirayama K, and Arakawa T. Intranasal administration of Schistosoma japonicum paramyosin induced robust long-lasting systemic and local antibody as well as delayed-type hypersensitivity responses, but it failed to confer protection in a mouse infection model. Jpn J Infect Dis 63:166-72. 2010
http://www.ncbi.nlm.nih.gov/pubmed/20495267
Mayuzumi, H., Inagaki-Ohara, K., Uyttenhove, C., Okamoto, Y., Matsuzaki, G. Interleukin-17A is required to suppress invasion of Salmonella enterica serovar Typhimurium to enteric mucosa. Immunology. 131 (3): 377-385, 2010.
http://dx.doi.org/10.1111/j.1365-2567.2010.03310.x
Miyata, T., T. Harakuni, T. Tsuboi, J. Sattabongkot, H. Kohama, M. Tachibana, G. Matsuzaki, M. Torii, and T Arakawa. Plasmodium vivax ookinete surface protein Pvs25 linked to cholera toxin B subunit induces potent transmission-blocking immunity by intranasal as well as subcutaneous immunization. Infect. Immun. 78: 3773-3782, 2010.
http://dx.doi.org/10.1128/IAI.00306-10
Okamoto, Y. Y., Umemura, M., Yahagi, A., O’Brien,, R. L. Ikuta, K, Kishihara, K., Hara, H., Nakae, S., Iwakura, Y. and Matsuzaki, G. Essential role of interleukin-17A in the formation of a mycobacterial infection-induced granuloma in the lung. J. Immunol. In press
http://dx.doi.org/10.4049/​jimmunol.0903332
Yahagi,, A. Umemura, M., Tamura, T., Kariyone, A., Begum, M. D., Kawakami, K., Okamoto, Y., Hamada, S., Oshiro, K., Kohama, H., Arakawa, T., Ohara, N., Takatsu, K. and Matsuzaki, G. Suppressed induction of mycobacterial antigen-specific Th1-type CD4+ T cells in the lung after pulmonary mycobacterial infection. Int. Immunol. in press.
http://dx.doi.org/10.1093/intimm/dxq010
Uechi G, Toma H, Arakawa T, Sato Y.Molecular characterization on the genome structure of hemolysin toxin isoforms isolated from sea anemone Actineria villosa and Phyllodiscus semoni. Toxicon 56:1470-6, 2010.
http://dx.doi.org/10.1016/j.toxicon.2010.09.002
Arakawa T, Tachibana M, Miyata T, Harakuni T, Kohama H, Matsumoto Y, Tsuji N, Hisaeda H, Stowers A, Torii M, Tsuboi T.Malaria ookinete surface protein-based vaccination via the intranasal route completely blocks parasite transmission in both passive and active vaccination regimens in a rodent model of malaria infection. Infect. Immun. 77:5496-5500, 2009.
http://dx.doi.org/10.1128/IAI.00640-09
Zhou H, Abiru N, Arakawa T, Sakima R, Miyata T, Kobayashi M, Fukushima K, Kawasaki E, Yamasaki H and Eguchi K. Oral administration of recombinant live yeast producing altered peptide ligand derived from insulin B:9-23 peptide linked to cholera toxin B subunit suppresses development of autoimmune diabetes in NOD mice. Acta Medica Nagasakiensia 54:33-38, 2009.
http://ci.nii.ac.jp/naid/110007463567/
Nozoye T, Takaiwa F, Tsuji N, Yamakawa T, Arakawa T, Hayashi Y, Matsumoto Y. Production of Ascaris suum As14 protein and its fusion protein with cholera toxin B subunit in rice seeds.  J Vet Med Sci. 71:995-1000、2009
http://dx.doi.org/10.1292/jvms.71.995
Harakuni T, Kohama H, Tadano M, Uechi G, Tsuji N, Matsumoto Y, Miyata T, Tsuboi T, Oku H, Arakawa T. Mucosal vaccination approach against mosquito-borne Japanese encephalitis virus. Jpn J Infect Dis. 62:37-45、2009.
http://www.ncbi.nlm.nih.gov/pubmed/19168957
Abdel-Hafeez EH, Kikuchi M, Watanabe K, Ito T, Yu C, Chen H, Nara T, Arakawa T, Aoki Y, Hirayama K. Proteome approach for identification of schistosomiasis japonica vaccine candidate antigen. Parasitol Int. 58:36-44, 2009.
http://dx.doi.org/10.1016/j.parint.2008.09.004
Matsumoto Y, Suzuki S, Nozoye T, Yamakawa T, Takashima Y, Arakawa T, Tsuji N, Takaiwa F, Hayashi Y. Oral immunogenicity and protective efficacy in mice of transgenic rice plants producing a vaccine candidate antigen (As16) of Ascaris suum fused with cholera toxin B subunit. Transgenic Res. 18:185-92. 2009.
http://dx.doi.org/10.1007/s11248-008-9205-4
Begum, M. D., Umemura, M., Yahagi, A., Okamoto, Y., Hamada, S., Ohshiro, K., and Matsuzaki, G. Accelerated induction of mycobacterial antigen-specific CD8+ T cells in the Mycobacterium tuberculosis-infected lung by subcutaneous vaccination with Mycobacterium bovis bacilli Calmette et Guérin. Immunology 128:556-563, 2009.
http://dx.doi.org/10.1111%2Fj.1365-2567.2009.03141.x
Kondo, K., Okuma, K., Tanaka, R., Matsuzaki, G., Ansari, A. A., and Tanaka, Y. Rapid induction of OX40 ligand on primary T cells activated under DNA-damaging conditions. Human Immunol. 69:533-542, 2008.
http://dx.doi.org/10.1016/j.humimm.2008.07.001
Kuba, M., Tsuha, K. Tsuha, K., Matsuzaki, G. and Yasumoto, T. In vivo analysis of the anti-allergic activities of Camellia japonica extract and Okicamelliaside, a degranulation Inhibitor. J. Health Sci. 54 (5): 584-588, 2008.
http://dx.doi.org/10.1248/jhs.54.584
Yoneda A, Tuchiya K, Takashima Y, Arakawa T, Tsuji N, Hayashi Y, Matsumoto Y. Protection of mice from rabies by intranasal immunization with inactivated rabies virus. Exp Anim. 57:1-9, 2008.
http://dx.doi.org/10.1538/expanim.57.1
Hamada, S., Umemura, M., Shiono, T., Tanaka, K., Yahagi, A., Begum, M. D., Oshiro, K., Okamoto, Y., Watanabe, H., Kawakami, K., Roark, C., Born, W. K., O’Brien, R., Ikuta, K., Ishikawa, H., Nakae, S., Iwakura, Y., Ohta, T. and Matsuzaki, G. IL-17A produced by gd T cells plays a critical role in innate immunity against Listeria monocytogenes infection in the liver. J. Immunol.181(5):3456-3463, 2008.
http://www.jimmunol.org/content/181/5/3456.short
Hamada, S., Umemuram M., Shiono, T., Hara, H., Kishihara, K., Tanaka, K., Mayuzumi, H., Ohta, T., Goro Matsuzaki. Importance of murine Vg1+ gd T cells expressing interferon-g and interleukin-17A in innate protection against Listeria monocytogenes infection. Immunology 125 (2):170-177, 2008.
http://dx.doi.org/10.1111/j.1365-2567.2008.02841.x
Kohama, K., Umemura, M., Okamoto, Y., Yahagi, A., Goga, H., Harakuni, T., Matsuzaki, G., Arakawa, T. Mucosal immunization with recombinant heparin-binding haemagglutinin adhesin suppresses extrapulmonary dissemination of Mycobacterium bovis bacillus Calmette-Guérin (BCG) in infected mice. Vaccine 26:924-932, 2008.
http://dx.doi.org/10.1016/j.vaccine.2007.12.005
Umemura, M., Yahagi, A., Hamada, S., Begum, M. D., Watanabe, H., Kawakami, K., Suda, T. Sudo, K., Nakae, S., Iwakura, Y., Matsuzaki, G. IL-17-mediated regulation of innate and acquired immune response against pulmonary Mycobacterium bovisbacilli Calmette-Guérin infection. J. Immunol. 178 (6):3786-3796, 2007.
http://www.ncbi.nlm.nih.gov/pubmed/17339477
Begum, M. D.,Umemura, M., Kon, S., Yahagi, A., Hamada, S., Oshiro, K., Gotoh, K., Nishizono, A., Uede, T.,Matsuzaki, G. Suppression of the bacterial antigen-specific T cell response and the dendritic cell migration to the lymph nodes by osteopontin. Microbiol. Immunol. 51(1):135-147, 2007.
http://www.ncbi.nlm.nih.gov/pubmed/17237609
Sakaguchi S, Arakawa T. Recent developments in mucosal vaccines against prion diseases. Expert review of vaccines, in press.
http://dx.doi.org/10.1586/14760584.6.1.75
Inagaki-Ohara K, Sasaki A, Matsuzaki G, Ikeda T, Hotokezaka M, Chijiiwa K, Kubo M, Yoshida H, Nawa Y, Yoshimura A. Suppressor of cytokine signalling-1 in lymphocytes regulates the development of intestinal inflammation in mice. Gut 55(2):212-219, 2006.
http://dx.doi.org/10.1136/gut.2004.062653
Yamanaka H, Ishibashi D, Yamaguchi N, Yoshikawa D, Nakamura R, Okimura N, Arakawa T, Tsuji T, Katamine S, Sakaguchi S. Enhanced mucosal immunogenicity of prion protein following fusion with B subunit of Escherichia coli heat-labile enterotoxin. Vaccine 24:2815-23 (2006).
http://dx.doi.org/10.1016/j.vaccine.2005.12.054
Kidoya, H., Umemura, M., Kawabe, T., Matsuzaki, G., Yahagi, A., Imamura, R. Suda, T. Fas Ligand Induces Cell-Autonomous IL-23 Production in Dendritic Cells, a Mechanism for Fas Ligand-Induced IL-17 Production. J. Immunol. 175 (12): 8024-8031, 2005.
http://www.ncbi.nlm.nih.gov/pubmed/16339539
Arakawa T, Komesu A, Otsuki H, Sattabongkot J, Udomsangpetch R, Matsumoto Y, Tsuji N, Wu Y, Torii M, Tsuboi T. Nasal immuth a malaria transmission-blocking vaccine candidate Pfs25 induces complete protective immunity in mice against field-isolated Plasmodium falciparum. Infect. Immun. 73:7375-7380 (2005).
Eto M., Harada, M., Tatsugami, K., Harano, M., Koga, H., Matsuzaki, G., and Naito, S. Anti-tumor activity of heat-shock protein 60-recognizing CD4+ T cells against syngeneic murine renal cell carcinoma. BJU Int. 2005 Feb;95(3):421-424.
http://dx.doi.org/10.1111/j.1464-410X.2005.05313.x
Uechi G, Toma H, Arakawa T, Sato Y. Molecular cloning and functional expression of hemolysin from the sea anemone Actineria villosa. Protein Expr. Purif. 40:379-384, 2005.
http://dx.doi.org/10.1016/j.pep.2004.12.003
Uechi G, Toma H, Arakawa T, Sato Y. Biochemical and physiological analyses of a hemolytic toxin isolated from a sea anemone Actineria villosa. Toxicon 45:761-766, 2005.
http://dx.doi.org/10.1016/j.toxicon.2005.01.015
Inagaki-Ohara, K., Sawaguchi, A., Suganuma, T., Matsuzaki, G., Nawa, Y. Intraepithelial lymphocytes express junctional molecules in murine small intestine. BBRC 331:977-983, 2005.
http://dx.doi.org/10.1016/j.bbrc.2005.04.025
Harakuni T, Sugawa H, Komesu A, Tadano M, Arakawa T. Heteropentameric cholera toxin B subunit chimeric molecules genetically fused to a vaccine antigen induce systemic and mucosal immune responses: a potential new strategy to target recombinant vaccine antigens to mucosal immune systems. Infect. Immun. 73:5654-5665 (2005).
http://dx.doi.org/10.1128/IAI.73.9.5654-5665.2005
Tomita, Y., Zhang, Q.-W., Matsuzaki, G., Shimizu, I., Iwai, T., Okano, S., Nomoto, K., Uasui, H. Absent mRNA accumulation of Th1 or Th2 cytokines in heart allografts with chimerism-based drug-induced tolerance. Surg. Today 35:364-370, 2005.
http://dx.doi.org/10.1007/s00595-004-2963-6
Shimizu, I., Tomita, Y., Iwai, T., Zhang, Q.-W., Matsuzaki, G, Nomoto, K., Yasui, H. The regulation function of Ly-49A, Ly-49D and Ly-49-G2 on NK cells in the recognition and rejection of the alloantigen in vivo. Transpl. Int. 18:1090-1099, 2005.
Inagaki-Ohara, K., Chinen, T., Matsuzaki, G., Sasaki,A., Sakamoto, Y., Hiromatsu, K. Nakamura-Uchiyama, F., Nawa Y. and Yoshimura, A..Mucosal T cells bearinggdT-cell receptor play a protective role in intestinal inflammation. J. Immunol. 2004 Oct 15;173(8):5156-64.
Umemura, M., Kawabe, T., Shudo, K., Kidoya, H.,Fukui, M., Asano, M., Iwakura, Y., Matsuzaki, G., Imamura, R., and Suda, T. Involvement of IL-17 in Fas ligand-induced inflammation. Int. Immunol. 2004 Aug;16(8):1099-108. Epub 2004 Jul 05.
http://dx.doi.org/10.1093/intimm/dxh111
Tagawa, T., Nishimura, H., Uajima, T., Hara, H., Kishihara, K., Matsuzaki, G., Yoshino, I., Maehara, Y. and Yoshikai, Y. Vδ1+γδ T cells producing CC chemokines may bridge a gap between neutrophils and macrophages in innate immunity during Eschericha coli infection in mice. J Immunol. 2004 Oct 15;173(8):5156-64
http://www.jimmunol.org/content/173/8/5156.abstract
Tsuji N, Miyoshi T, Islam MK, Isobe T, Yoshihara S, Arakawa T, Matsumoto Y, Yokomizo Y. Recombinant Ascaris 16-kDa protein induces protection against Ascaris suum larval migration following intranasal vaccination in pigs.J. Infect. Dis. 190:1812-1820, 2004.
http://dx.doi.org/10.1086/425074
Takeda F, Arakawa T, Toma H, Ishii A, Sato Y. Intranasal sensitization with Blomia tropicalis antigens induces allergic responses in mice characterized by elevated antigen-specific and non-specific serum IgE and peripheral blood eosinophil counts. Rev. Inst. Med. Trop. Sao Paulo. 46:1-8, 2004.
http://www.ncbi.nlm.nih.gov/pubmed/15057325
Islam MK, Miyoshi T, Isobe T, Kasuga-Aoki H, Arakawa T, Matsumoto Y, Yokomizo Y, Tsuji N. Temperature and metal ions-dependent activity of the family I inorganic pyrophosphatase from the swine roundworm Ascaris suum. J. Vet. Med. Sci. 66:221-223, 2004.
http://www.ncbi.nlm.nih.gov/pubmed/15031556
Umemura, M., Nishimura, H., Saito, K., Yajima, T., Matsuzaki, G., Mizuno, S., Sugawara,I., and Yoshikai, Y. Interleukin-15 as an immune adjuvant to increase the efficacy of Mycobacterium bovis bacillus Calmette-Guerin vaccination. Infect. Immune. 71 (10): 6045-6048, 2003.
http://dx.doi.org/10.1128/IAI.71.10.6045-6048.2003
Chen, M., Mun, H.-S., Piao, L.-X., Aozai, F., Norose, K., Mohamed, R. M., Belal, U S., Fang, H., Ahmed, A. K., Kang, H.-K., Matsuzaki, G., Kitamura, D., and Yano, A. Induction of protective immunity by primed B-1 cells in Toxoplasma gondii-infected B cell-deficient mice. Microbiol. Immunol. 47 (12): 97-103, 2003.
http://www.ncbi.nlm.nih.gov/pubmed/14695450
Arakawa T Molecular farming for the production of therapeutic proteins. Chin. J. Biochem. Biophys. 35:307, 2003.
Tsuji N, Suzuki K, Kasuga-Aoki H, Isobe T, Arakawa T, Matsumoto Y. Mice intranasally immunized with a recombinant 16-kilodalton antigen from roundworm Ascaris parasites are protected against larval migration of Ascaris suum. Infect. Immun. 71:5314-5323, 2003.
http://dx.doi.org/10.1128/IAI.71.9.5314-5323.2003
Toma H, Kobayashi J, Imada Y, Arakawa T, Nakajima Y, Laymanivong S, Vannachone B, Manivong K, Phompida S, Sato Y. Field application and evaluation of a rapid immunochromatographic test for detection of Plasmodium falciparum infection among the inhabitants of Lao PDR. Southeast Asian J. Trop. Med. Public Health 34:43-47, 2003.
http://www.ncbi.nlm.nih.gov/pubmed/12971513
Islam MK, Miyoshi T, Kasuga-Aoki H, Isobe T, Arakawa T, Matsumoto Y, Tsuji N. Inorganic pyrophosphatase in the roundworm Ascaris and its role in the development and molting process of the larval stage parasites. Eur. J. Biochem. 270:2814-2826, 2003.
http://dx.doi.org/10.1046/j.1432-1033.2003.03658.x
Arakawa T, Tsuboi T, Kishimoto A, Sattabongkot J, Suwanabun N, Rungruang T, Matsumoto Y, Tsuji N, Hisaeda H, Stowers A, Shimabukuro I, Sato Y, Torii M. Serum antibodies induced by intranasal immunization of mice with Plasmodium vivax Pvs25 co-administered with cholera toxin completely block parasite transmission to mosquitoes. Vaccine21:3143-3148, 2003.
http://dx.doi.org/10.1016/S0264-410X(03)00258-5
Umphress S, Timiryasova T, Arakawa T, Hilliker S, Fodor I, and Langridge W. Vaccinia virus mediated expression of human APC induces apoptosis in colon cancer cells. Transgenics 4:19-33, 2003.
http://www.oldcitypublishing.com/Transgenics/TRANSabstacts/Trans4.1abstracts/TRANSv4n1p19-33Umphress.html
Tachiiri, A., Imamura, R., Wang, Y.,Fukui, M.,Umemura, M., and Suda, T.: Genomic structure and inducible expression of the IL-22 receptor α chain in mice. Genes Immun., 4:153-159, 2003.
http://dx.doi.org/10.1038/sj.gene.6363934
Fukui, M., Imamura, R., Umemura, M.,Kawabe, T., and Suda, T.: Pathogen-associated molecular patterns sensitize macrophages to Fas ligand-induced apoptosis and IL-1β release. J. Immunol., 171:1868-1874, 2003.
http://www.jimmunol.org/content/171/4/1868.short
Matsuzaki, G., Yamada, H., Kishihara, K., Yoshikai, Y., and Nomoto, K. Mechanism of murine Vg1+ gd T cell-mediated innate immune response against Listeria monocytogenes infection. Eur. J. Immunol. 32 (4): 928-935, 2002.
Wossene A, Tsuji N, Kasuga-Aoki H, Miyoshi T, Isobe T, Arakawa T, Matsumoto Y, Yoshihara S. Lung stage protein profile and antigenic relationship between Ascaris lumbricoides and Ascaris suum. J. Parasitol. 88:826-828. (2002)
http://dx.doi.org/10.1645/0022-3395(2002)088[0826:LSPPAA]2.0.CO;2
Tsuji N, Kasuga-Aoki H, Isobe T, Arakawa T, Matsumoto Y. Cloning and characterization of a highly immunoreactive 37 kDa antigen with multi-immunoglobulin domains from the swine roundworm Ascaris suum. International J. Parasitol. 32:1739-1746.(2002)
http://dx.doi.org/10.1016/S0020-7519(02)00179-0
Kasuga-Aoki H, Tsuji N, Suzuki K, Matsumoto Y, Arakawa T, Isobe T. Molecular characterization of a glyceraldehydes-3-phosphate dehydrogenase from the swine roundworm Ascaris suum. Mol. Biochem. Parasitol. 119:135-139. (2002)
Wossene A, Tsuji N, Kasuga-Aoki H, Miyoshi T, Isobe T, Arakawa T, Matsumoto Y, Yoshihara S. Species-specific proteins identified in Ascaris lumbricoides and Ascaris suum using two-dimentional electrophoresis. Parasitol. Res. 88:868-871. (2002)
http://dx.doi.org/10.1007/s00436-002-0640-5
Shimizu, H., Matsuguchi, T., Fukuda, Y., Nakano, I., Hayakawa, T., Takeuchi, O., Akira, S., Umemura, M., Suda, T., and Yoshikai, Y.: Toll-like receptor 2 contributes to liver injury by Salmonella infection through Fas ligand expression on NKT cells in mice. Gastroenterology, 123:1265-1277, 2002.
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  • 琉球大学 熱帯生物圏研究センター 熱帯感染生物学部門 分子感染防御学分野/医学研究科 生体防御学分野